2.2 Possible ways to cure

 2.2 Possible ways to cure

Antibiotics, such as doxycycline or penicillin, are used to cure leptospirosis and therefore should be administered early on in the course of the illness. antibiotics intravenously for those with serious conditions. Anyone who exhibits leptospirosis-like symptoms needs to see a doctor. Situations when medical advice is needed, are when there is direct or indirect contact with one's pet's urine, blood, or tissues while it is ill, helping to deliver newborns from an infectious agent and common symptoms, such as fever, muscle aches, and headaches, appear within three weeks of a high level of exposure. The interval between initial infection and the progression of the disease is typically 5 to 14 days but can be as short as a day. It is simple to contract leptospirosis from an infected animal and its surroundings. By vaccinating your pets, managing rodent populations, maintaining well hygienic practices, wearing protective gear, and getting care as soon as you feel sick to break the cycle of illness, a strong animal immunisation programme is essential, and this includes recognising modern farming's potential risks.

2.2.1 Test kit design

The OnSite Leptospira IgG/IgM Combo Rapid Test is a lateral flow chromatographic immunoassay that may be carried out by workers with minimal training in 15-20 minutes without any need for laboratory apparatus. IgG and IgM antibodies to Leptospira interrogans (L. interrogans) in human serum, plasma, or whole blood are simultaneously detected and distinguished with this test. It is intended for use as a screening test by healthcare professionals and offers a preliminary test result to help with the diagnosis of L. interrogans infection. Any assessment or application of this test result must also take into account further clinical findings and the experts' clinical decision-making.

2.2.2 Leptospirosis test kit features: 

Figure 9. Leptospira IgG/IgM Combo Rapid Test by CTK Biotech

1. Accuracy: 100% specificity and 100% sensitivity in comparison with a reference rapid test on the market

2. Cross Reactivity: No false-positive results were observed on specimens from TP, HIV, Dengue, TB, Typhoid Ab, HBsAg, HCV Ab, HEV Ab, H.P Ab, HAV, HCG, RF, ANA, HAMA

3. Interference: No interference were seen with substances

4. Salicylic acid: 4.34 mmol/L; Glucose: 55 mmol/L

5. Sodium citrate: 3.8 %; Heparin: 3,000 U/L

6. Creatinine:  442 μmol/L 

7. Bilirubin:  20 mg/dL

8. EDTA: 3.4 μmol/L

9. Haemoglobin: 2g/L

10. Human IgG: 1000 mg/dL

11. AlbuminL 60 g/L